Onset of pyoderma gangrenosum after tocilizumab therapy for Takayasu arteritis: A new undescribed paradoxical reaction

A case of primarily facial pyoderma gangrenosum associated with Takayasu arteritis

IL: interleukin PG: pyoderma gangrenosum TA: Takayasu arteritis INTRODUCTION Pyoderma gangrenosum (PG) is a type of neutrophilic dermatosis that shows noninfectious ulcers characterized by neutrophil infiltration of the skin. PG is frequently associatedwith systemic diseases such as inflammatory bowel disease, rheumatoid arthritis, and hematologic disorders. In Japan, PG is also awellknown comp...

An Unusual Association of Chronic Recurrent Multifocal Osteomyelitis, Pyoderma Gangrenosum, and Takayasu Arteritis.

Successful Tocilizumab Treatment in a Child With Refractory Takayasu Arteritis

Takayasu arteritis (TA) in the child remains a therapeutic challenge because corticosteroids and conventional immunosuppressive agents are not always safe or efficacious. The complex formed by interleukin6 (IL-6) and soluble IL-6 receptor appears to play a pivotal role in the pathogenesis of TA. We describe a favorable response to the anti-IL-6 receptor antibody tocilizumab (TCZ) in a child wit...

Successful tocilizumab treatment in a child with refractory Takayasu arteritis.

Takayasu arteritis (TA) in the child remains a therapeutic challenge because corticosteroids and conventional immunosuppressive agents are not always safe or efficacious. The complex formed by interleukin-6 (IL-6) and soluble IL-6 receptor appears to play a pivotal role in the pathogenesis of TA. We describe a favorable response to the anti-IL-6 receptor antibody tocilizumab (TCZ) in a child wi...

Pyoderma Gangrenosum after Augmentation Mammoplasty

A 43-year-old woman with an unremarkable previous medical history underwent a bilateral mammoplasty augmentation with silicone prostheses. Five days later, she developed small ulcers with pustules on the surgical wound, which progressed in periphery to affect the whole breasts, with a necrotic base, ®brin deposition and raised, thickened edges. The lesions were symmetrical and the areolas were ...